Meeting Banner
Abstract #4526

Effects of Lactoferrin on Altered Brain Metabolism in Pup Rats After Prenatal Exposure to Dexamethasone

Yohan van de Looij1,2, Pierre Larvaron1, Emmanuel Somm1, Bing Wang3, Rolf Gruetter2,4, Stphane V. Sizonenko1, Petra S. Hppi1

1Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Department of Nutrition and Health, Nestl Research Center, Lausanne, Switzerland; 4Department of Radiology, University of Geneva and Lausanne, Geneva and Lausanne, Switzerland

Rat model of glucocorticoids exposure during gestation has shown reduction in brain weight. At P7, alterations of cerebral metabolism in the cortex and the hippocampus have been observed by in vivo 1H-MRS. Lactoferrin (Lf) is an iron-binding glycoprotein secreted in milk which has an antioxidant activity. The aim of this work was to evaluate the neuroprotective effect of Lf following prenatal exposure to glucocorticoids by high field localized 1H-MRS. Neurochemical profiles of the pup rat brains confirmed the altered brain development after Dex exposure and revealed the potential protective effect of Lf given to gestational and lactating dams.