Sung-Tak Hong1, Dvid Zsolt Balla1,
Gunamony Shajan1, Changho Choi2, Kamil Ugurbil3,
Rolf Pohmann1
1High-Field Magnetic Resonance Center ,
Max-Planck Institute for Biological Cybernetics, Tuebingen,
Baden-Wuerttemberg, Germany; 2Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Center
for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN,
United States
In
vivo 1H NMR spectroscopy has several problems including narrow spectral
dispersion and low SNR. Increasing a static field strength could alleviate
these problems, providing feasibilities of quantifying metabolites not
observable at lower field strength. The acquisition of an enhanced
neurochemical profile was obtained by minimizing TE up to 1.7 ms in a STEAM
sequence at 16.4T. The technique demonstrated possibilities of quantification
of additional metabolites, acetate and ethanolamine, in the rat brain in
vivo.