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Abstract #4528

Localized in Vivo 1H NMR Spectroscopy of the Rat Brain at 16.4T

Sung-Tak Hong1, Dvid Zsolt Balla1, Gunamony Shajan1, Changho Choi2, Kamil Ugurbil3, Rolf Pohmann1

1High-Field Magnetic Resonance Center , Max-Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

In vivo 1H NMR spectroscopy has several problems including narrow spectral dispersion and low SNR. Increasing a static field strength could alleviate these problems, providing feasibilities of quantifying metabolites not observable at lower field strength. The acquisition of an enhanced neurochemical profile was obtained by minimizing TE up to 1.7 ms in a STEAM sequence at 16.4T. The technique demonstrated possibilities of quantification of additional metabolites, acetate and ethanolamine, in the rat brain in vivo.