Patrick John Bolan1, Eva H. Baker2, Lance Jay DelaBarre1, Hellmut Merkle3, Doug Yee4, Michael T. Nelson5, Lenore Everson5, Michael Garwood1
1Radiology/CMRR, University of Minnesota, Minneapolis, MN, United States; 2Diagnostic Radiology Department, NIH Clinical Center, Bethesda, MD, United States; 3National Institute Neurological Disorders and Stroke, NIH, Bethesda, MD, United States; 4Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States; 5Radiology, University of Minnesota, Minneapolis, MN, United States
While 1H MRS is increasingly being used in clinical studies of breast cancer, there has been some evidence that the use of Gadolinium-based contrast agents prior to MRS can affect the spectra, broadening the choline resonance and reducing its area. This work describes a study performing 1H MRS at 4T before and after a bolus of Gd-DTPA. It was found that after the contrast injection there was a small negative impact on both the choline and water peaks, with an effect size of 10-15%.