Assessing the Accuracy of a Commercial Computer Aided Diagnosis Package (CADstream) in Determining the Level of Disease Post Neoadjuvant Chemotherapy in a Cohort of Breast Cancer Patients

Martin D. Pickles¹, Lindsay W. Turnbull¹

CADstream is a computer aided diagnosis package developed to aid in the interpretation of breast MR. Reports have demonstrated that CADstream provides quicker interpretation, increased specificity and greater correlation with histological size. However, these reports are based on the assessment of pre-treatment lesions and not post chemotherapy lesions where a treatment induced vascular shutdown is anticipated. The aim of this study was to assess CADstreams accuracy post chemotherapy. In conclusion this study demonstrated by reducing the enhancement and difference thresholds the sensitivity can be increased resulting in fewer false negative results.