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Abstract #4578

Computational Analysis of Flow in the Portal Vein of Normal Subjects and Patients Using MRI and CFD

Stephanie M. George1, Diego R. Martin2, Don P. Giddens1

1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; 2Department of Radiology, Emory University School of Medicine, Atlanta, GA, United States

With the incidence of chronic liver disease (CLD) increasing the need for improved diagnostic measurements has increased. Magnetic resonance imaging (MRI) and phase-contrast MR offer noninvasive techniques which provide both high quality anatomical and hemodynamic data. The use of these data coupled with computational fluid dynamics (CFD) to provide detailed flow field information is a novel approach. This study examines a small number of normal subjects and patients comparing PC-MR measured portal venous hemodynamic parameters including velocity and flow rate and computational results. This work demonstrates the feasibility of coupling MRI and CFD to investigate the altered hemodynamics in CLD.