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Abstract #4611

MRI Assessment of Dynamic Lung Volume Changes in Subjects Using a Nasal Expiratory Positive Airway Pressure (NEPAP) Device

Ding Xia1, Elan J. Grossman1, D M. Rapoport2, I Ayappa2, A V. Patel2, L Daugherty3, Jian Xu1, Kelly Anne Mcgorty1, Qun Chen1

1Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, United States; 2Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, United States; 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

The purpose of the current study is to use a real-time MRI technique for measuring lung volume changes caused by using a nasal expiratory positive airway pressure (nEPAP) device, a new treatment for obstructive sleep apnea (OSA). This may help us better understand the mechanism by which it treats OSA. Our results show there is an increase in functional reserve capacity (FRC) while using the nEPAP device. Since end-expiratory hyperinflation is likely to produce increased traction in the trachea, this suggests the main action of the nasal expiratory device may be to stiffen the upper airway through increased longitudinal traction.