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Abstract #4620

Functional Magnetic Resonance Imaging of Liver: Effect of Glucose

muhammad E. Haque1, Ioannis Koktzoglou1, Wei Li1, Jo Ann Carbray1, Pottumarthi V. Prasad1

1Radiology, North Shore University Healthcare System, Evanston, IL, United States

One of the primary functions of insulin is disposal of glucose from the blood and inhibition of hepatic glucose production (HGP). Dysfunction of either of these processes can cause development of type II diabetes. Incomplete suppression of HGP is a strong indication of insulin resistance and may be an early marker for development of type II diabetes. Current methods to evaluate insulin resistance are complicated, invasive and hence not used in routine practice. Here we demonstrate feasibility of using BOLD MRI to monitor oxygenation changes in the liver following glucose which may be related to insulin sensitivity.