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Abstract #4639

Breath-Hold Quantitative Liver MR Imaging: Assessment of Hepatic Fibrosis, Iron Content, and Fat Fraction

Russell Norman Low1,2, Huanzhou Yu3, Ann Shimakawa3, Lloyd Estkowski, Richard Ehman4

1Sharp and Children's MRI Center, San Diego, CA, United States; 2San Diego Imaging, San Diego, CA, United States; 3Applied Science Lab, General Electric Healthcare; 4Mayo Clinic

Quantification of diffuse liver disease adds a new dimension to hepatic MR imaging which can provide critical information for diagnosis and for monitoring response to therapy. We explore the implementation of a rapid breath-hold MR evaluation of liver fibrosis using MR Elastography combined with a new multiecho Dixon technique known as IDEAL Quant which quantifies liver iron assessed by R2* values and fat fraction. In five breath holds this exam assesses liver fibrosis, R2* correlated with iron content, and the percentage of fatty infiltration.