Ran-Chou Chen1,2, Chen-Te Chou3,4
1Biomedical Imaging and Radiological
Science, National Yang-Ming Medical University, Taipei, Taiwan; 2Radiology,
Taipei City Hospital , Taiwan; 3Radiology, Chang-Hua Christian
Hospital, Er-lin branch, Chang-Hua, Taiwan; 4Department of
Biomedical Imaging and Radiological Science, National Yang-Ming Medical
University, Taipei, Taiwan
Our
study was to evaluate ferucarbotran-enhanced MRI with accumulation-phase fat
suppression T1-weighted imaging in comparison with gadolinium-enhanced MRI
for characterization of T1W hyperintense nodules within cirrhotic liver. In
the gadolinium-enhanced group, the MRI sensitivity, specificity and accuracy
were 60%, 100% and 73%, respectively. In ferucarbotran-enhanced group, the
sensitivity, specificity and accuracy were 100%, 83% and 94%, respectively.
The ferucarbotran-enhanced MRI provided additional information of cellular
function in differentiation of focal hepatic lesion and ferucarbotran-enhanced
MRI is superior to gadolinium-enhanced MRI in characterization of T1W
hyperintense nodules. T1W hyperintense nodule depicting hyperintense on
ferucarbotran-enhanced accumulation-phase FS-T1WI should be investigated
aggressively.