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Abstract #4656

DTI and 2D MR Spectroscopy of Hepatitis C in 3T

Rajakumar Nagarajan1, Manoj K. Sarma1, Charles Hinkin2, Steven Castellon2, Jason P. Smith3, Homayoon Khanlou4, Laveeza Bhatti4, Jonathan Truong5, Ann B. Ragin6, Elyse Singer7, M Albert Thomas1

1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2Department of Psychiatry & Biobehavioral Sciences, UCLA School of Medicine and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States; 3Veteran's Affairs Greater Los Angeles Healthcare Center; 4AIDS Healthcare Foundation, Westside Clinic, Los Angeles; 5Kaiser Permanente, Lancaster CA; 6Northwestern University, Chicago, Illinois, USA; 7Neurology, UCLA School of Medicine, Los Angeles, California, United States

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). HCV infection sometimes results in an acute illness, but most often becomes a chronic condition that can lead to cirrhosis of the liver and liver cancer. Hepatitis C may be detectable with MR diffusion tensor imaging (DTI), which is exquisitely sensitive to water diffusion and is used to quantify the magnitude of diffusivity and the orientation and linearity (that is, anisotropy) of water motility in microstructural level in brain. Combining two-dimensional (2D) localized correlated spectroscopic (L-COSY) technique with DTI provides more information about the cerebral metabolites, mean diffusivity and fractional anisotropy changes in patients with hepatitis C.