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Abstract #4668

The Effect of High Fat or High Carbohydrate Meals on the Gastrointestinal Tract: A MRI Study

Eleanor F. Cox1, Michael Mellows2, Susan E. Pritchard1, Mahamoud Hussein1, Caroline L. Hoad1, Carolyn Costigan3, Luca Marciani2, Robin C. Spiller2, Penny A. Gowland1

1SPMMRC, Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, NIHR BRU, Nottingham University Hospitals, Nottingham, United Kingdom; 3Brain & Body Centre, University of Nottingham, Nottingham, United Kingdom

The effect of a high fat (HF) meal and an equicaloric high carbohydrate (HC) meal on satiety, gastric volumes, small bowel water content (SBWC) and gallbladder contraction (as a marker of CCK release) was investigated using MRI. The HF meal resulted in increased fullness and decreased hunger and appetite compared with the HC meal. Gastric emptying was initially faster for the HF meal. After 90 minutes, SBWC was greater after the HF meal than after the HC meal. This delayed increase may reflect delayed emptying of fat which stimulates pancreatic secretions.