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Abstract #4673

In Vivo 31P MR Spectroscopy of Human Placenta

Jan Weis1, Kathrine Bjersand2, Anna Karin Wikstrm2, Mats Olovsson2, Johan Wikstrm3

1Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden; 2Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; 3Department of Oncology, Radiology and Clinical Immunology, Uppsala University , Uppsala, Sweden

31P image-selected in vivo spectroscopy (ISIS) with proton decoupling and nuclear Overhauser effect enhancement was used for measurement the spectra of placental tissue in vivo. Major metabolites of normal human placenta and placentas from women with preeclampsia were quantified. Our results demonstrate that the 31P MRS is able to measure spectra of the placenta with acceptable quality and measurement time. 31P MRS is a promising tool to detect in vivo changes of human placental metabolites.