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Abstract #4727

Comparison of Liver Steatosis Quantification by MRS at 4.7 T and Histology on Ob/ob and Db/db Mice

Fanny Noury1,2, Alain Fautrel3,4, Eric Hitti1,2, Pascale Bellaud3, Herv Saint-Jalmes1,2, Bernard Fromenty4, Pierre-Antoine Eliat2

1LTSI - INSERM U642 - Universit Rennes 1, Rennes, France; 2PRISM - IFR 140 BiogenOuest - Universit Rennes 1, Rennes, France; 3Plate-forme dHistopathologie - IFR 140 BiogenOuest - Universit Rennes 1, Rennes, France; 4FMC - INSERM U991 - IFR 140 - Universit Rennes 1, Rennes, France

Murine models of obesity such as ob/ob (leptin deficient) and db/db (leptin receptor deficient) mice are extensively used in different scientific fields including pharmacology and toxicology. Besides increased body fatness, hyperlipidemia and insulin resistance these mice develop moderate (db/db) or massive (ob/ob) steatosis. In some studies a longitudinal follow-up of steatosis may be warranted, to assess the beneficial (or deleterious) effects of chronic drug administration. In this preliminary study, db/db and ob/ob mice were used to determine whether magnetic resonance spectroscopy could be a reliable non-invasive method to evaluate fatty liver, using statistical comparison with histological results.