Fanny Noury1,2, Alain Fautrel3,4,
Eric Hitti1,2, Pascale Bellaud3, Herv Saint-Jalmes1,2,
Bernard Fromenty4, Pierre-Antoine Eliat2
1LTSI - INSERM U642 - Universit Rennes 1, Rennes, France; 2PRISM
- IFR 140 BiogenOuest - Universit Rennes 1, Rennes, France; 3Plate-forme
dHistopathologie - IFR 140 BiogenOuest - Universit Rennes 1, Rennes,
France; 4FMC - INSERM U991 - IFR 140 - Universit Rennes 1,
Rennes, France
Murine
models of obesity such as ob/ob (leptin deficient) and db/db (leptin receptor
deficient) mice are extensively used in different scientific fields including
pharmacology and toxicology. Besides increased body fatness, hyperlipidemia
and insulin resistance these mice develop moderate (db/db) or massive (ob/ob)
steatosis. In some studies a longitudinal follow-up of steatosis may be
warranted, to assess the beneficial (or deleterious) effects of chronic drug
administration. In this preliminary study, db/db and ob/ob mice were used to
determine whether magnetic resonance spectroscopy could be a reliable
non-invasive method to evaluate fatty liver, using statistical comparison
with histological results.