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Abstract #4792

Creatine and N-Acetylaspartate Concentrations Are Associated with P53 Status in Astrocytoma

Tracy Richmond McKnight1, Kenneth J. Smith1, Susan Chang2, Mitchel S. Berger2

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Neurological Surgery, UCSF, San Francisco, CA

Abnormal function of p53 protein may result in compromised DNA repair and reduced apoptosis leading to increased tumor density and resistance to DNA-damaging therapies. We hypothesized that a downstream function of p53 might be an alteration in cell metabolism. We compared the HRMAS MRS profile of astrocytoma with normal (p53wt) and abnormal (p53ab) p53. Cre and NAA were lower and cell density was higher in p53ab tumors. No correlations were observed between any of the IHC and metabolic parameters. These findings suggest that p53 may influence the energy production and cell density of astrocytoma; however, the exact mechanisms remain unclear.