Jose
Manuel Morales1, Ana Gonzalez-Segura2, Jose
Gonzalez-Darder3, Concha Lopez-Gines1, Miguel
Cerda-Nicolas1, Daniel Monleon4
1Universitat
de Valencia, Valencia, Spain; 2CIBER-BBN, Valencia, Spain; 3Hospital
Clinico Universitario de Valencia, Valencia, Spain; 4Fundacion
Investigacion Hospital Clinico Valencia, Valencia, Spain
GBM
and AA are neoplasic entities of the CNS, with high biological and clinical
aggressiveness. Metabolic phenotyping of high grade glioma may provide new
information for better management of this disease. In this communication, we
show high grade glioma molecular profiles and metabolic subgroups based on
HRMAS spectra of 31 high grade glioma biopsies. One of the subgroups, which
includes most AA samples, reflects a less aggressive type of tumour with
lower levels of phosphocholine. Metabolic discrimination between these subgroups
according to the PCA, include the levels of some metabolites which can be
seen by MRS in vivo.
Keywords