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Abstract #4809

Quantitative Correlation of Volume Transfer Coefficient Ktrans with Histopathologic Grades of Gliomas

Na Zhang1,2, Zhengsheng Deng2, Li Meng3, XiaoYi Wang3, Weihua Liao3, Bob L. Hou4

1Paul C. Lauterbur Research Center for Biomedical Imaging,Paul C. Lauterbu, Chinese Academy of Science , Shenzhen, Guangdong, China; 21Institute of Biomedical Engineering, School of Info-physics and Geomatics Engineering,, Central South University, Changsha, Hunan, China; 3Department of Radiology, XiangYa Hospital of School of Medicine, Central South University, Changsha, Hunan, China; 4Radiology, West Virginia University, Morgantown, WV, United States

The breakdown of blood-brain barrier (BBB) in gliomas results in the increment of microvascular permeability: a surrogate marker to assess malignant degree of gliomas. The volume transfer coefficient of contrast agent (CA) from plasma space to extravascular extracellular space (EES), as defined Ktrans, has been used to characterize the microvascular permeability quantitively. Since knowing the grades of gliomas for administration of the tumor treatments is very important, and there were only few reports for applying T1 perfusion MRI data for evaluating grades of glioma, in current study we presented the results of correlation of Ktrans and histopathologic grades of gliomas by using the T1-weighted dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) method and a modified Tofts' model, and also investigated to apply Ktrans, Kep, Kel, Ve, and Vp obtained from the T1 perfusion data analyses for evaluating grades of the gliomas.