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Abstract #4811

Quantitative Osteosarcoma DCE-MRI: How Long Is the Acquisition Time Necessary?

Ya Wang1, Wei Huang2, David M. Panicek1, Laurence H. Schwartz1, Jason A. Koutcher1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States; 2Oregon Health & Science University, Portland, OR, United States

Based on actual Ktrans and Ve values from 18 osteosarcoma patients, simulated DCE-MRI time-courses were reconstructed with varying scan time length to estimate minimal acquisition time needed to derive accurate and stable pharmacokinetic parameters. The results suggest that for typical osteosarcoma necrosis percentage range, 5 min DCE-MRI scan time is adequate.