Ya Wang1, Wei Huang2, David M.
Panicek1, Laurence H. Schwartz1, Jason A. Koutcher1
1Memorial Sloan Kettering Cancer
Center, New York, NY, United States; 2Oregon Health & Science
University, Portland, OR, United States
Based
on actual Ktrans and Ve values from 18 osteosarcoma patients, simulated
DCE-MRI time-courses were reconstructed with varying scan time length to
estimate minimal acquisition time needed to derive accurate and stable
pharmacokinetic parameters. The
results suggest that for typical osteosarcoma necrosis percentage range, 5
min DCE-MRI scan time is adequate.
Keywords