Inna V. Linnik1,2, Neil Woodhouse3,
Marietta Scott3, Carsten Liess3, Jean J. Tessier3,
Herv Barjat3, Geoffrey J.M. Parker1,4, John C.
Waterton3,5, Josephine H. Naish1,4
1Imaging Science and Biomedical
Engineering, School of Cancer and Imaging Sciences, University of Manchester,
Manchester, United Kingdom; 2Biomedical Imaging Institute,
University of Manchester, Manchester,
United Kingdom; 3Imaging, Translational Sciences, AstraZeneca,
Alderley Park, Macclesfield, Cheshire, United Kingdom; 4Biomedical
Imaging Institute, University of Manchester, Manchester, United Kingdom; 5
Biomedical Imaging Institute, University of Manchester, Manchester, United
Kingdom
Recent
studies have suggested that oxygen-enhanced (OE) MRI can potentially be used
for assessing regional changes of oxygen delivery and accumulation in tumours
when switching from breathing air to 100% oxygen, based on T1-shortening due
to dissolved molecular oxygen. However while many tumours do show the domains
with expected R1 increase, we have previously observed regions exhibiting
apparent R1 reduction.