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Abstract #4833

Evaluation of the Effect of Anti-Angiogenic Therapy on Tumor Vasculature in Breast Cancer Mouse Xenograft

Yoshinori Kato1, Wenlian Zhu1, Shruthi Shankar1, Venu Raman1, Susanta K. Sarkar2, Zaver M. Bhujwalla1, Dmitri Artemov1

1JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Medicines Development, Oncology R&D, GlaxoSmithKline, Collegeville, PA, United States

The biological mechanisms underlying anti-angiogenic therapy when used in combination with conventional cytotoxic treatment are still not entirely understood. We have evaluated the effect of anti-angiogenic therapy on tumor vasculature with MRI and tumor hypoxia with optical imaging. Anti-angiogenic therapy transiently decreased tumor hypoxia, but induced tumor hypoxia post-treatment possibly due to the reduction of vascular volume in the tumor. Our results provide further insights as to whether anti-angiogenic therapy induces the normalization of the tumor vasculature, which improves drug delivery by reducing hypoxia, an important environmental factor in tumor resistance.