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Abstract #4839

In Vivo MRI Follow-Up of Murine Tumors Treated by Electrochemotherapy with Bleomycin.

Lucie Calmels1, Bassim Al-Sakere2,3, Lluis Mir2,3, Jean-Pierre Ruaud4, Anne Leroy-Willig4

1U2R2M, University Paris-Sud XI , Orsay, 91405, France; 2CNRS UMR 8121, Institut Gustave Roussy, Villejuif, 94805, France; 3UMR 8121, University Paris-Sud XI , Orsay, 91405; 4U2R2M, University Paris-Sud XI, Orsay, 91405, France

Sixteen mice bearing grafted fibrosarcoma were treated with electrotransfer without (E), after a low (B) and a high (HB) dose of bleomycin.Volume, ADC and T2 of tumors were measured before and after treatment. Bleomycin induced a volume decrease depending on the dose. ADC reached a maximum at 24 and 10 hrs for B and HB group respectively. T2 was increased during a few hours after application of electric field in the three groups.