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Abstract #4949

T2-Weighted Spin Echo Pulse Sequence That Is Sensitive to Restricted Diffusion

Ziqi Sun1, Robert Bartha2

1The Ohio State University, Columbus, OH, United States; 2Robarts Research Institute, London, Ontario, Canada

A spin-echo (SE) pulse sequence incorporated with two selective adiabatic full passage (AFP) pulse trains separated by a time delay tau (varying with TE) and located symmetrically on both sides of an amplitude modulated 180 degree refocusing pulse. Apparent T2 and diffusion measurements on a phantom of multi-medium and multi-compartment demonstrated that the customized SE sequence generated T2-weighted contrast that is specifically sensitive to restricted diffusion in the phantom media in comparison to those of the conventional SE and CPMG pulse sequences.