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Abstract #4978

In Vivo Comparison of Three Quantitative MRI Techniques to Measure Brain Iron

Catherine Anusha Mallik1, Gareth J. Barker1, David J. Lythgoe1

1Centre for Neuroimaging Sciences, Institute of Psychiatry, London, United Kingdom

Correlation of quantitative MRI with brain iron may prove a useful tool in the diagnosis and prognosis of associated neuropathology. Sequences required for three of the most promising measures were implemented: transverse relaxation rate, magnetic susceptibility and magnetic field correlation (MFC) mapping. Protocols for each technique were standardised for brain coverage under the constraint of approximately equal, patient tolerable, scan times. Data collected on three control subjects at 3T in six brain regions indicated that magnetic susceptibly is the most closely correlated with reference brain iron of the three techniques.