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Abstract #5053

Improvement of the Arterial Input Function Considering B1-Inhomogeneities

Robert Merwa1, Karin Kapp2, Franz Ebner3, Thorsten Feiweier4, Gernot Reishofer3, Rudolf Stollberger5

1Medical Engineering, FH O - Upper Austria University of Applied Sciences, Linz, Austria; 2Department of Radiation Therapy, Medical University of Graz, Graz, Austria; 3Department of Radiology, Medical University of Graz, Graz, Austria; 4Healthcare, Siemens AG, Germany; 5Institute of Medical Engineering, Graz University of Technology, Graz, Austria

DCE MRI was performed at 3 T in combination with a special sequence in order to determine B1 inhomogenities. AIF and tissue concentrations were calculated and the kinetic parameters Ktrans and Ve were determined with a generalized kinetic model. The absolute deviation of the maximum value of two comparable AIFs can be improved by a factor up to 70 and the root mean square deviation concerning the two AIFs can be decreased by a factor up to 30 if B1 inhomogeneities are corrected. Also the deviations of Ktrans and Ve in respect of the two AIFs are significantly lower.