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Abstract #5079

Quantitative Analysis of Projection Breast Density Changes at Different Compression Angles Based on 3D MRI

Tzu-Ching Shih1,2, Jeon-Hor Chen2,3, D Chang3, K Nie3, M Lin3, O Nalcioglu3, Min-Ying Lydia Su3

1Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States

This study aims to demonstrate the effect of compression angle on the projection breast density at different compression ratios based on the patient-specific three-dimensional MR images. The fibroglandular tissue and tatty tissue were described by 3,488 and 11,803 tetrahedral elements. Within 50% to 70% compression ratio, the variation of the measured projection breast density was approximately 7%. In contrast, the variation of the projection breast density was nearly 11% for MOL view compression. This study provides a novel computer simulation approach to simulate the large deformation of breast compression. Compression angle of deviation may affect the measured projection breast density.