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Abstract #5082

DIVA+QUADRANT: Novel Visualisation Software for DCE-MRI to Aid Breast Cancer Diagnosis and Neoadjuvant Chemotherapy Monitoring

Martin Lowry1, David John Manton1, Martin D. Pickles1, Lindsay W. Turnbull1

1YCR Centre for MR Investigations, Hull-York Medical School, Hull, East Yorkshire, United Kingdom

The clinical utility of dynamic contrast-enhanced MRI (DCE-MRI) is well established, but the analysis of data by radiologists can be time-consuming. Novel visualisation software, called DIVA+QUADRANT, has been developed which quickly and clearly indicates those regions within a tumour which display the highest contrast agent enhancement (uptake) rate and the greatest degree of contrast agent wash out (signal decay); both well-established indicators of malignancy following the BIRADS-MRI lexicon. The software can also be used to monitor response to chemotherapy as it can map out areas where enhancement and washout rates have decreased, i.e. areas where vasculature shutdown is occurring.