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Abstract #5084

Non-Rigid Motion Compensation in MR Prostate Perfusion Imaging

Gert Wollny1, Isabel Casanova1, Thomes Hambrock2, Andres Santos1, Maria Jesus Ledesma-Carbayo1

1BIT-DIE, ETSI Telecomunicacin, UPM, Madrid, Spain; 2Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Dynamic Contrast enhance MRI has been established as accurate method in detection and localization of prostate cancer. Time series of three-dimensional datasets of the prostate are acquired and used to obtain per-voxel signal-intensity vs. time curves. These are then used to differentiate cancerous from non-cancerous tissue. However, rectal peristalsis and patient movement may result in spatial-mismatching of the serial datasets and, therefore, incorrect enhancement curves. In this work, we present a method based on image registration to compensate for these movements, and validate the method by comparing pre-and postregistration intensity time curves to manually obtained ones.