John David Dickson1, Guy Barnett Williams2,
Thomas Adrian Carpenter2, Richard E. Ansorge1
1Department of Physics, Cambridge
University, Cambridge, Cambridgeshire, United Kingdom; 2Wolfson
Brain Imaging Centre, Cambridge University, Cambridge, Cambridgeshire, United
Kingdom
It
has been suggested that extracellular fluid spins undergo bulk dephasing from
those in intracellular fluid. This study provides direct evidence for this
phenomenon and exploits it to make quantitative measurements of both the
intra/extracellular fluid volume fractions and precession frequencies. This
is achieved by fitting the data from a Gradient Echo Sampling of a Free
Induction Decay (GESFID) sequence with a complex signal model.