Bing Yao1, Francesca Bagnato2,
Eiji Matsuura2, Hellmut Merkle1, Peter van Gelderen1,
Henry McFarland2, Jeff H. Duyn1
1AMRI, NINDS, National Institutes of
Health, Bethesda, MD, United States; 2Neuroimmunology Branch,
NINDS, National Institutes of Health
High
field magnetic susceptibility-weighted MRI provides information on healthy
and diseased human brain. Although the sources that contribute to the R2* and
frequency shifts associated with susceptibility contrast are not fully
understood, previous studies suggest that iron and myelin content may
contribute. In this study, we used in-vivo and post-mortem brain tissues of
multiple sclerosis (MS) as a model of disease to investigate the contribution
of tissue iron and myelin content to the image contrast. We found that the
iron and myelin may affect phase and R2* differently.
Keywords