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Abstract #5144

Quantitative Magnetization Transfer Imaging in Postmortem Brain at 3T Using BSSFP

Michaela Soellinger1, Christian Langkammer1,2, Thomas Seifert-Held1, Nikolaus Krebs2, Monika Gloor3, Eva Scheurer2, Klaus Scheffler3, Franz Fazekas1, Stefan Ropele1

1Department of Neurology, Medical University of Graz, Graz, Austria; 2Ludwig Boltzmann Institute for Clinical-Forensic Imaging, Graz, Austria; 3Department of Radiology, University Hospital Basel, Basel, Switzerland

A crucial issue in determining quantitative magnetization transfer (qMT) parameters using balanced steady state free precession (bSSFP) is the estimation of the on-resonant singularity of the superlorentzian absorption line shape G0. We present an empirical G0 calibration method for postmortem in-situ brain scans at 3T using cross-linked BSA (bovine serum albumin) probes. For the investigated temperature range from 6-20C G0 resulted in 2.0*10-5. First qMT results of three postmortem in-situ brain scans revealed decreased bound pool size ratios f in white matter compared to in-vivo scans.