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Abstract #5146

Susceptibility-Corrected Magnetization Transfer Contrast in a Mouse Model of Glioblastoma Multiforme at 9.4 T

David Rudko1,2, Martyn Klassen2, Susan Meakin2, Ravi Menon2

1Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada; 2Robarts Research Institute, London, Ontario, Canada

In this study, magnetization transfer (MT) imaging was applied to a mouse model of GBM at 9.4 T. The goals of this work were: a) to quantify the MT effect in tumour core and in normal-appearing white matter and (b) to compensate for susceptibility differences which alter the MT effect at 9.4 T. The MTR in tumour core was observed to increase significantly from 14.60.5% to 15.30.6% using a field-map based static field correction. Further, the MTR asymmetry increased in two disparate regions of tumour to values of 15.30.6% and 13.20.5% relative to in normal-appearing white matter (MTRasym = 10.71.6%)