Abstract #5149
Correlation Time
Diffusion MRI of Mouse Liver at 11.7T: Magnetization Transfer Effects
Hernan Jara1, Stephan W. Anderson1,
Osamu Sakai1, Jorge A. Soto1
1Boston
University School
of Medicine, Boston, MA, United States
Purpose:
To map the correlation time diffusion coefficient (CT-D) of ex vivo liver
samples imaged at 11.7T and to compare results quantitatively vs. the
standard pulsed-field gradient (PFG-D) diffusion MRI. Methods: A CT-D algorithm
was applied to mouse liver images obtained with Tandem-TSE at 11.7T. Results:
Excellent quantitative agreement was found between this non-PFG diffusion
technique vs. the standard PFG diffusion technique. Conclusion: CT-D
diffusion MRI is a viable alternative to standard PFG-diffusion MRI that
produces higher SNR and is less demanding on the imaging gradients. This work
could have implications for diffusion MRI microscopy.
