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Abstract #0006

Super-Resolution Track-Density Imaging Studies of Mouse Brain: Comparison to Histology

Fernando Calamante1,2, Jacques-Donald Tournier1,2, Nyoman D. Kurniawan3, Zhengyi Yang3, Erika Gyengesi4, Graham J. Galloway3, David C. Reutens3, Alan Connelly1,2

1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 3Centre for Advanced Imaging, the University of Queensland, Brisbane, Queensland, Australia; 4Neuroscience Research Australia, Randwick, New South Wales, Australia

The recently introduced super-resolution track-density imaging (TDI) is able to increase the spatial resolution of the reconstructed images beyond the acquired MRI resolution by incorporating information contained in whole-brain fibre-track modelling results. The TDI technique not only provides a means to achieve super-resolution, but it also provides very high anatomical contrast with a new MRI contrast mechanism. However, the anatomical information-content of this novel contrast mechanism has not been validated yet. We perform such a study using ex vivo mouse brains acquired at 16.4T, and comparing the results of the super-resolution TDI technique to histological staining.