Abstract #0006

Super-Resolution Track-Density Imaging Studies of Mouse Brain: Comparison to Histology

Fernando Calamante^1,2, Jacques-Donald Tournier^1,2, Nyoman D. Kurniawan³, Zhengyi Yang³, Erika Gyengesi⁴, Graham J. Galloway³, David C. Reutens³, Alan Connelly^1,2

¹Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; ²Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; ³Centre for Advanced Imaging, the University of Queensland, Brisbane, Queensland, Australia; ⁴Neuroscience Research Australia, Randwick, New South Wales, Australia

The recently introduced super-resolution track-density imaging (TDI) is able to increase the spatial resolution of the reconstructed images beyond the acquired MRI resolution by incorporating information contained in whole-brain fibre-track modelling results. The TDI technique not only provides a means to achieve super-resolution, but it also provides very high anatomical contrast with a new MRI contrast mechanism. However, the anatomical information-content of this novel contrast mechanism has not been validated yet. We perform such a study using ex vivo mouse brains acquired at 16.4T, and comparing the results of the super-resolution TDI technique to histological staining.