Jeremy Joseph Flint1,2, Brian Hansen3, Sharon Portnoy1,2, Choong H. Lee2,4, Michael A. King5, Michael Fey6, Franck Vincent6, Peter Vestergaard-Poulsen3, Stephen J. Blackband2,7
1Neuroscience, University of Florida, Gainesville, Fl, USA; 2McKnight Brain Institute, University of Florida, Gainesville, Fl, USA; 3Center for Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark; 4Electrical Engineering, University of Florida, Gainesville, Fl, USA; 5Pharmacology & Therapeutics, University of Florida, Gainesville, Fl, USA; 6Bruker Biospin; 7National High Magnetic Field Laboratory, Talahassee, Fl, USA
The ability to resolve microstructural details of biological tissues has been a long sought-after goal in the field of MR imaging. Magnetic resonance microscopy (MRM) has evolved to reveal ever-finer details of the cellular organization which makes up tissue parenchyma. Such techniques are needed so that we may understand the primary structural origins underlying MR signal changes resultant from pathology. In the current study, we report what we believe to be the first instances of cellular imaging in humans and neural process imaging in humans and pigs using magnetic resonance microscopy techniques.