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Abstract #0015

Regional Quantification of Myocardial Stiffness using MR Elastography

Arunark Kolipaka1, Kiaran McGee1, Shivani Aggarwal1, Qingshan Chen1, Nandan Anavekar1, Armando Manduca1, Richard Ehman1, Philip Araoz1

1Mayo Clinic, Rochester, MN, USA

The mechanical properties of the myocardium are known to be essential for normal cardiac function. Magnetic resonance elastography (MRE) is a noninvasive phase contrast technique to estimate stiffness of soft tissues. The purpose of this study was to regionally quantitate effective stiffness in infarcted and remote, non-infarcted myocardium using MRE. Post 3 weeks of induced infarction on 13 pigs, MRE and mechanical testing was performed. We found significant difference in stiffness estimates between infarcted and remote, non-infarcted myocardium both using MRE and mechanical testing.