Abstract #0022

Assessment of Chemical Exchange Saturation Transfer Effects in Myocardial Tissue at 7T

Mohammad Haris¹, Anup Singh¹, Kejia Cai¹, Walter R. T. Witschey², James J. Pilla¹, Giovanni Ferrari³, Kevin Koomalsingh³, Robin Hinmon³, Gerald Zsido¹, Joseph H. Gorman III³, Robert C. Gorman³, Hari Hariharan¹, Ravinder Reddy¹

¹CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, USA; ²University Hospital Freiburg, Germany; ³Department of Surgery, University of Pennsylvania

We observed the chemical exchange saturation transfer (CEST) effects of water signal in left ventricular infarcted swine heart tissue on 7T clinical scanner. Significantly low CEST contrast was observed in infarcted region compared to non-infarcted region. Low CEST contrast in infarcted region may be due to combined effect from decreased concentration of creatine and low pH. Further characterization of this method on in-vivo animal model of myocardial infarction is in progress.