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Abstract #0082

Double-PFG MR Imaging of the CNS: Probing Underlying Grey Matter Microstructure

Noam Shemesh1, Daniel Barzany2, Ofer Sadan3, Yuval Zur4, Daniel Offen5, Yaniv Assaf2, Yoram Cohen1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel; 2Department of Neurobiology, Tel Aviv University, Israel; 3Department of Neurology, Tel-Aviv Medical Center, Tel Aviv University, Israel; 4GE Healthcare, Israel; 5Laboratory of Neurosciences, Felsenstein Medical Research Center, Department of Neurology, Rabin Medical Center & Tel Aviv University, Israel

Double-Pulsed-Field-Gradient (d-PFG) MR is emerging as a useful methodology for depicting underlying microstructural information in scenarios where conventional single-PFG (s-PFG) are very limited, such as when anisotropic compartments are randomly oriented. Here, we used d-PFG MRI on phantoms, pig spinal cord and rat brain. The angular variations in the E() data could be easily observed for all specimens even in the raw data; furthermore, the presence of modulated E() plots in grey matter tissues revealed that water is diffusing in randomly oriented anisotropic compartments having different eccentricities, which appeared as different patterns within the cortex of the rat brain.