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Abstract #0098

Double-PFG MR as a Novel Means for Characterizing Microstructures in Grey Matter

Noam Shemesh1, Ofer Sadan2, Daniel Offen3, Yoram Cohen1

1School of Chemistry, the Raymond & Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; 2Department of Neurology, Tel-Aviv Medical Center & the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Laboratory of Neurosciences, Felsenstein Medical Research Center, Department of Neurology, Rabin Medical center, Israel

Double-Pulsed-Field-Gradient (d-PFG) MR is emerging as a promising methodology for characterizing underlying microstructural features in randomly oriented anisotropic compartments, which are difficult to characterize using conventional diffusion MR methods. Here, d-PFG spectroscopy was performed on isolated pig grey matter (GM). Angular dependencies in the E() plots were observed, indicating the presence of compartment shape and microscopic anisotropies in the grey matter. Angular d-PFG MRI was then performed in the rat brain ex-vivo, showing that different GM regions indeed yield different angular patterns, thus reporting on different underlying microstructures within the GM. Therefore, d-PFG MRI is promising for characterizing GM tissues.