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Abstract #0105

Layer-Specific Interhemispheric Functional Connectivity in Rat S1fl Revealed by Laminar Electrode Recordings & Resting State fMRI

Kwangyeol Baek1,2, Woo Hyun Shim1,2, Jaeseung Jeong1, Harsha Radhakrishnan2, Bruce R. Rosen2, David A. Boas2, Maria Franceschini2, Young Ro Kim2

1Bio & Brain Engineering, KAIST, Daejeon, Korea, Republic of; 2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA

Recently, spontaneous BOLD fluctuations in MRI have been reported to be correlated between functionally interconnected brain regions. However, it is not yet clear whether such correlation arises from the synchronized neural activity. In the present study, using laminar electrophysiological recordings, we demonstrated spontaneous neural activities in bilateral primary somatosensory cortices (S1) and layer-specific pattern in interhemispheric functional connectivity. Interestingly, similar pattern was replicated in the resting state BOLD MRI. The fine laminar arrangement in the interhemispheric neural connectivity, e.g. corpus callosum, may mediate the interhemispheric neural communication.