Ovidiu Cristian Andronesi1, Borjan A. Gagoski2, Elfar Adalsteinsson2, A. Gregory Sorensen1
1Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; 2Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
The overlap of spectra in magnetic resonance spectroscopy limits the unambiguous identification and quantification of metabolites. Novel correlation chemical shift imaging sequences using optimized low power adiabatic excitation and fast spiral spatial encoding are demonstrated on 3T clinical scanners for two-dimensional COSY (Correlation Spectroscopy) and TOCSY (Total Correlation Spectroscopy) experiments. These methods could reveal metabolites that are otherwise obscured in 1D spectra. To date there has been limited progress reported towards a feasible and robust multivoxel COSY. TOCSY imaging is shown for the first time in this work. Results on phantoms, volunteers and patients with brain tumors are presented.