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Abstract #0201

Detection & Quantification of Holmium-166 Loaded Microspheres in Patients with Liver Metastases: Initial Experience within the Framework of a Phase I Study

Gerrit Hendrik van de Maat1, Mattijs Elschot2, Peter Roland Seevinck1, Hendrik de Leeuw1, H.W. de Jong3, M. L. Smits3, M. A. van den Bosch3, M. G. Lam3, B. A. Zonnenberg3, A. D. van het Schip3, J. Frank Nijsen3, Chris J. Bakker1

1Image Sciences Institute, University Medical Center, Utrecht, Netherlands; 2Department of Radiology & Nuclear Medicine, University Medical Center, Utrecht , Netherlands; 3Department of Radiology & Nuclear Medicine, University Medical Center, Utrecht, Netherlands

We report the first results of the detection and quantification of Holmium-166 loaded microspheres in patients with liver metastases that were treated within the framework of a clinical phase I study. HoMS concentration maps determined from T2* weighted data acquired using a multi gradient echo sequence show good correspondence with activity maps acquired with Single Photon Emission Computed Tomography (SPECT). The total amount of HoMS in the liver determined from the concentration maps was in good agreement with the total amount that was delivered to the liver. The HoMS were found to mainly accumulate at the tumor site.