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Abstract #0221

Myocardial ASL Perfusion Reserve Test Detects Angiographic CAD in Initial Cohort of 29 Patients

Zungho Zun1, Terrence Jao1, Padmini Varadarajan2, Ramdas G. Pai3, Eric C. Wong4, Krishna S. Nayak1

1Department of Electrical Engineering, University of Southern California, Los Angeles, CA, USA; 2Division of Cardiology, Loma Linda University Medical Center, Loma Linda, CA, USA; 3Division of Cardiology, Loma Linda University Medical Center, Loma Linda , CA, USA; 4Departments of Radiology & Psychiatry, University of California, San Diego, La Jolla, CA, USA

Rest-stress myocardial arterial spin labeled (ASL) MRI was performed in twenty-nine patients with suspected coronary artery disease (CAD). Perfusion reserve was estimated in six myocardial segments of a single mid short-axis slice, and compared with X-ray angiography. Receiver operating characteristic (ROC) curves were analyzed for (i) detection of patients with angiographic CAD and (ii) detection of the most ischemic segments. The area under ROC curves were (i) 0.88 and (ii) 0.71.