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Abstract #0227

Fast Macromolecular Proton Fraction Mapping From a Single Off-Resonance Magnetization Transfer Measurement

Vasily L. Yarnykh1

1Radiology, University of Washington, Seattle, WA, USA

This study demonstrates the feasibility of fast and accurate macromolecular proton fraction (MPF) mapping using only a single-offset MT-weighted image. This approach is the fastest to date quantitative MT (qMT) method, which requires no extra time compared to traditional magnetization transfer ratio (MTR) mapping, if a complementary T1 map is available. Since the proposed method rapidly determines MPF with high accuracy, it provides a viable alternative to both time-consuming multi-parameter qMT techniques and fast but poorly-interpretable MTR measurements.