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Abstract #0238

MEMRI Atlas of Neonatal Mouse Brain Development

Kamila Urszula Szulc1, Brian J. Nieman2, Edward Jospeh Houston1, Alexandra L. Joyner3, Daniel H. Turnbull1,4

1Kimmel Center for Biology & Medicine at the Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, NY, USA; 2Mouse Imaging Center, Hospital for Sick Children, Toronto, Canada; 3Developmental Biology Program, Sloan-Kettering Institute, New York, NY, USA; 4Radiology, NYU School of Medicine, New York, NY, USA

MEMRI approach is particularly well suited to visualize brain anatomy and it has been successfully used to do so in mice in vivo at embryonic to adult stages. Here, we have extended MEMRI for longitudinal studies of brain development in individual mice during the critical early postnatal period. Based on these data, a brain atlas was created, consisting of individual and average brains at 11 developmental stages, from postnatal day 1 (P1) to P11. The database generated in this project will serve as an important resource for future phenotypic MEMRI analyses of mutant mice with brain defects.