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Abstract #0251

Treatment Effects of Diffuse Intrinsic Pontine Gliomas On Tumor & Normal Appearing Cortical Gray Matter Assessed By Arterial Spin Labeling Perfusion & 3D Volumetric Measurements

Jan Sedlacik1,2, Claudia M. Hillenbrand1, Alberto Broniscer3

1Radiological Sciences, St. Jude Childrens Research Hospital, Memphis, TN, USA; 2Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3Oncology, St. Jude Childrens Research Hospital, Memphis, TN, USA

In a clinical trial of combined antiangiogenic and local radiation therapy (RT) of brainstem gliomas changes in tumor and cortical grey matter (GM) perfusion were closely monitored by arterial spin labeling and volumetric measurements. Median tumor perfusion was found to be increased and showing a higher variance directly after RT suggesting different tumor responses to treatment compared to tumor volume which decreased in all patients. A temporary drop in cortical GM perfusion and volume was found directly after baseline which may be caused by steroids, given at the beginning of therapy.