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Abstract #0255

Short Term Measurement Reproducibility of Perfusion Fraction (F), Pseudo-Diffusion Coefficient (D*) & Diffusion Coefficient (D) in Colorectal Liver Metastases Derived By Intravoxel Incoherent Motion Analysis of Respiratory-Triggered Diffusion-Weighted MR Imaging

Adrian Andreou1, Matthew Orton2, David J. Collins1,2, Martin O. Leach2, Dow-Mu Koh1

1Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom

Applying the principles of intravoxel incoherent motion (IVIM) allows quantitative parameters which reflect tissue microcapillary perfusion and tissue diffusivity to be derived. We evaluated the short term measurement reproducibility of the perfusion fraction (f), pseudo-diffusion (D*) and diffusion coefficients (D) of normal appearing liver and colorectal liver metastases in patients. We found that D showed good to moderate measurement reproducibility in liver and metastases. However, the reproducibility of f and D* was relatively poor but using a Bayesian method for analysis significantly improved the reproducibility of f and D* in metastases and D* in the liver.