Abstract #0257

Assessment of Hepatocellular Carcinoma in Fresh Liver Explants using a Non-Gaussian Diffusion Kurtosis Model.

Andrew B. Rosenkrantz¹, Eric E. Sigmund¹, Benjamin E. Niver¹, Glyn R. Morgan², Bradley Spieler¹, Anthony G. Gilet¹, Cristina H. Hajdu³

¹Radiology, NYU Langone Medical Center, New York, USA; ²Transplant Surgery, NYU Langone Medical Center, New York, USA; ³Pathology, NYU Langone Medical Center, New York, NY, USA

Eight fresh liver explants in patients with hepatocellular carcinoma (HCC) underwent ex-vivo 1.5T MRI, including diffusion kurtosis imaging (DKI). ADC using mono-exponential (ADC) and non-Gaussian (D) fit, as well as mean kurtosis (K), were calculated. There was significant correlation between ADC and D, but not between ADC or D with K. Relative contrast between liver and HCC was greater for K than for ADC or D. ADC and D were lowest in non-necrotic HCC, while K was not different between viable and necrotic HCC. Alternate diffusion protocols may have potential for DKI of HCC following chemo-embolization in a clinical setting.