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Abstract #0264

31P MRS at 7T Shows a Relation Between the Alkaline Ph Compartment Content Compared to Phosphocreatine Recovery Kinetics At 1.5T

Joep van Oorschot1, Hermien Kan2, Andrew Webb2, Klaas Nicolay1, Jeroen Jeneson1

1Biomedical NMR, University of Technology Eindhoven, Eindhoven, Noord-Brabant, Netherlands; 2C. J. Gorter Center for High Field MRI, Dept. of Radiology, Leiden University Medical Center, Leiden, Netherlands

Non-invasive assessment of mitochondrial content in skeletal muscle, during rest, using 31P spectroscopy would be a major improvement over conventional methods, including kinetics of phosphocreatine (PCr) recovery from exercise. Previous research at 7T attributed a peak at 5.2 ppm to the Pi pool inside the mitochondrial matrix (Pi2). In this study we obtained further evidence for this hypothesis, by showing a correlation between Pi2 intensity assessed at 7T to the PCr recovery rate as assessed during in-magnet exercise at 1.5T. Studies were done in both endurance trained athletes and normally active subjects.