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Abstract #0270

Lipid Accumulation & Mitochondrial Function in Skeletal Muscle of ATGL Knockout Mice: A 31P MRS Study

Patricia M. Nunes1, Andor Veltien1, Henk Arnts2, Tineke van de Weijer3, Patrick Shrauwen3, Cees J. Tack4, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Central Animal Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3Human Biology, NUTRIM, School of Nutrition, Toxicology & Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands; 4Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands


Absence of adipose-triglyceride-lipase(ATGL), mainly expressed in muscle and adipose tissue, leads to triglyceride accumulation and decreased free-fatty-acid availability, boosting glucose metabolism. Here, we tested muscle mitochondrial oxidative capacity of ATGL-KO mice, in vivo, with dynamic 31PMRS, simultaneously with force measurements.