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Abstract #0278

Temporal Evolution of Cardiac Function in Mice with Myocardial Hypertrophy & Heart Failure

Bastiaan J. van Nierop1, Elza D. van Deel2, Dirk J. Duncker2, Gustav J. Strijkers1, Klaas Nicolay1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

In this study the temporal evolution of cardiac function was studied in C57BL/6 mice with a mild constriction of the aorta, resulting in compensated hypertrophy, and in mice with a severe constriction of the aorta. Only the mice with a severe constriction showed a progressive increase in left ventricular mass accompanied by a progressive decline of left and right ventricular ejection fraction, as well as lung edema. The different disease progression between both animal models opens unique opportunities to study interventions, and to study different aspects of myocardial hypertrophy during the transition from compensated hypertrophy towards overt HF.