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Abstract #0309

Metabolite Concentration Changes during Visual Stimulation using Functional Magnetic Resonance Spectroscopy (Fmrs) on a Clinical 7T Scanner

Benoit Michel Schaller1, Ralf Mekle2, Lijing Xin3, Rolf Gruetter1,4

1Laboratory of Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; 2Physikalisch-Technische Bundesanstalt, Berlin, Germany; 3Department of Radiology, University of Lausanne, Lausanne, Switzerland; 4Department of Radiology, Universities of Lausanne and Geneva, Switzerland

Functional MR Spectroscopy allows direct measurement of low concentrated metabolites with small concentration changes (<0.2mol/g) during neuronal activation providing insight into brain metabolism. In this study, the inter-subject analysis revealed an increase of [Lac] of 203%, [Glu] of 105% and a decrease of [Asp] of 54% in the visual cortex during the activation. The use of SPECIAL sequence at 7T yielded increased SNR compared to STEAM providing a twofold time resolution for the time courses of different metabolites concentration (Lac and Glu). Fewer scans had to be averaged to enable reliable metabolite quantification.